Ontology highlight
ABSTRACT:
SUBMITTER: Wen QJ
PROVIDER: S-EPMC4674320 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Wen Qiang Jeremy QJ Yang Qiong Q Goldenson Benjamin B Malinge Sébastien S Lasho Terra T Schneider Rebekka K RK Breyfogle Lawrence J LJ Schultz Rachael R Gilles Laure L Koppikar Priya P Abdel-Wahab Omar O Pardanani Animesh A Stein Brady B Gurbuxani Sandeep S Mullally Ann A Levine Ross L RL Tefferi Ayalew A Crispino John D JD
Nature medicine 20151116 12
Primary myelofibrosis (PMF) is characterized by bone marrow fibrosis, myeloproliferation, extramedullary hematopoiesis, splenomegaly and leukemic progression. Moreover, the bone marrow and spleens of individuals with PMF contain large numbers of atypical megakaryocytes that are postulated to contribute to fibrosis through the release of cytokines, including transforming growth factor (TGF)-β. Although the Janus kinase inhibitor ruxolitinib provides symptomatic relief, it does not reduce the muta ...[more]