Ontology highlight
ABSTRACT:
SUBMITTER: Mack SJ
PROVIDER: S-EPMC4674356 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Human immunology 20150928 12
HLA genotyping via next generation sequencing (NGS) poses challenges for the use of HLA allele names to analyze and discuss sequence polymorphism. NGS will identify many new synonymous and non-coding HLA sequence variants. Allele names identify the types of nucleotide polymorphism that define an allele (non-synonymous, synonymous and non-coding changes), but do not describe how polymorphism is distributed among the individual features (the flanking untranslated regions, exons and introns) of a g ...[more]