Lamination Speeds the Functional Development of Visual Circuits.
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ABSTRACT:
SUBMITTER: Nikolaou N
PROVIDER: S-EPMC4674658 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Lamination Speeds the Functional Development of Visual Circuits.
Nikolaou Nikolas N Meyer Martin P MP
Neuron 20151119 5
A common feature of the brain is the arrangement of synapses in layers. To examine the significance of this organizational feature, we studied the functional development of direction-selective (DS) circuits in the tectum of astray mutant zebrafish in which lamination of retinal ganglion cell (RGC) axons is lost. We show that although never laminar, the tuning of DS-RGC axons targeting the mutant tectum is normal. Analysis of mutant tectal neurons at late developmental stages reveals that directi ...[more]
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