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An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment.


ABSTRACT: The gastrointestinal tract is a challenging anatomical target for diagnostic and therapeutic procedures for bleeding, polyps and cancerous growths. Advanced endoscopes that combine imaging and therapies within the gastrointestinal tract provide an advantage over stand-alone diagnostic or therapeutic devices. However, current multimodal endoscopes lack the spatial resolution necessary to detect and treat small cancers and other abnormalities. Here we present a multifunctional endoscope-based interventional system that integrates transparent bioelectronics with theranostic nanoparticles, which are photoactivated within highly localized space near tumours or benign growths. These advanced electronics and nanoparticles collectively enable optical fluorescence-based mapping, electrical impedance and pH sensing, contact/temperature monitoring, radio frequency ablation and localized photo/chemotherapy, as the basis of a closed-loop solution for colon cancer treatment. In vitro, ex vivo and in vivo experiments highlight the utility of this technology for accurate detection, delineation and rapid targeted therapy of colon cancer or precancerous lesions.

SUBMITTER: Lee H 

PROVIDER: S-EPMC4674684 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment.

Lee Hyunjae H   Lee Youngsik Y   Song Changyeong C   Cho Hye Rim HR   Ghaffari Roozbeh R   Choi Tae Kyu TK   Kim Kyung Hoon KH   Lee Young Bum YB   Ling Daishun D   Lee Hyuk H   Yu Su Jong SJ   Choi Seung Hong SH   Hyeon Taeghwan T   Kim Dae-Hyeong DH  

Nature communications 20151130


The gastrointestinal tract is a challenging anatomical target for diagnostic and therapeutic procedures for bleeding, polyps and cancerous growths. Advanced endoscopes that combine imaging and therapies within the gastrointestinal tract provide an advantage over stand-alone diagnostic or therapeutic devices. However, current multimodal endoscopes lack the spatial resolution necessary to detect and treat small cancers and other abnormalities. Here we present a multifunctional endoscope-based inte  ...[more]

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