Ontology highlight
ABSTRACT:
SUBMITTER: Khan MR
PROVIDER: S-EPMC4674814 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Khan Mohammed Repon MR Li Liying L Pérez-Sánchez Consuelo C Saraf Anita A Florens Laurence L Slaughter Brian D BD Unruh Jay R JR Si Kausik K
Cell 20151201 6
Memories are thought to be formed in response to transient experiences, in part through changes in local protein synthesis at synapses. In Drosophila, the amyloidogenic (prion-like) state of the RNA binding protein Orb2 has been implicated in long-term memory, but how conformational conversion of Orb2 promotes memory formation is unclear. Combining in vitro and in vivo studies, we find that the monomeric form of Orb2 represses translation and removes mRNA poly(A) tails, while the oligomeric form ...[more]