Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez HH
PROVIDER: S-EPMC4674978 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Fernandez Hubert H HH Standaert David G DG Hauser Robert A RA Lang Anthony E AE Fung Victor S C VS Klostermann Fabian F Lew Mark F MF Odin Per P Steiger Malcolm M Yakupov Eduard Z EZ Chouinard Sylvain S Suchowersky Oksana O Dubow Jordan J Hall Coleen M CM Chatamra Krai K Robieson Weining Z WZ Benesh Janet A JA Espay Alberto J AJ
Movement disorders : official journal of the Movement Disorder Society 20141224 4
Motor complications in Parkinson's disease (PD) are associated with long-term oral levodopa treatment and linked to pulsatile dopaminergic stimulation. L-dopa-carbidopa intestinal gel (LCIG) is delivered continuously by percutaneous endoscopic gastrojejunostomy tube (PEG-J), which reduces L-dopa-plasma-level fluctuations and can translate to reduced motor complications. We present final results of the largest international, prospective, 54-week, open-label LCIG study. PD patients with severe mot ...[more]