Ontology highlight
ABSTRACT:
SUBMITTER: Shelton LM
PROVIDER: S-EPMC4676083 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Shelton Luke M LM Lister Adam A Walsh Joanne J Jenkins Rosalind E RE Wong Michael H L MH Rowe Cliff C Ricci Emanuele E Ressel Lorenzo L Fang Yongxiang Y Demougin Philippe P Vukojevic Vanja V O'Neill Paul M PM Goldring Christopher E CE Kitteringham Neil R NR Park B Kevin BK Odermatt Alex A Copple Ian M IM
Kidney international 20150930 6
The transcription factor Nrf2 exerts protective effects in numerous experimental models of acute kidney injury, and is a promising therapeutic target in chronic kidney disease. To provide a detailed insight into the regulatory roles of Nrf2 in the kidney, we performed integrated transcriptomic and proteomic analyses of kidney tissue from wild-type and Nrf2 knockout mice treated with the Nrf2 inducer methyl-2-cyano-3,12-dioxooleano-1,9-dien-28-oate (CDDO-Me, also known as bardoxolone methyl). Aft ...[more]