ConStrains identifies microbial strains in metagenomic datasets.
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ABSTRACT:
SUBMITTER: Luo C
PROVIDER: S-EPMC4676274 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
ConStrains identifies microbial strains in metagenomic datasets.
Luo Chengwei C Knight Rob R Siljander Heli H Knip Mikael M Xavier Ramnik J RJ Gevers Dirk D
Nature biotechnology 20150907 10
An important fraction of microbial diversity is harbored in strain individuality, so identification of conspecific bacterial strains is imperative for improved understanding of microbial community functions. Limitations in bioinformatics and sequencing technologies have to date precluded strain identification owing to difficulties in phasing short reads to faithfully recover the original strain-level genotypes, which have highly similar sequences. We present ConStrains, an open-source algorithm ...[more]
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