Towards comprehensive analysis of protein family quantitative stability-flexibility relationships using homology models.
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ABSTRACT:
SUBMITTER: Verma D
PROVIDER: S-EPMC4676804 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Towards comprehensive analysis of protein family quantitative stability-flexibility relationships using homology models.
Verma Deeptak D Guo Jun-Tao JT Jacobs Donald J DJ Livesay Dennis R DR
Methods in molecular biology (Clifton, N.J.) 20140101
The Distance Constraint Model (DCM) is a computational modeling scheme that uniquely integrates thermodynamic and mechanical descriptions of protein structure. As such, quantitative stability-flexibility relationships (QSFR) that describe the interrelationships of thermodynamics and mechanics can be quickly computed. Using comparative QSFR analyses, we have previously investigated these relationships across a small number of protein orthologs, ranging from two to a dozen [1, 2]. However, our ult ...[more]
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