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Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures.

ABSTRACT: We report a novel strategy for regiospecific hetero-assembly of DNA-modified gold nanoparticles (DNA-AuNPs) onto upconversion nanoparticles (UCNPs) into hybrid lab-on-a-particle systems. The DNA-AuNPs have been assembled onto the hexagonal plate-like UCNPs with well-regulated stoichiometry and controlled organization onto the different facets of UCNP, forming various addressable superstructures. The fine-tuning of stoichiometry and organization is realized by biorecognition specificity of DNA toward specific crystal facets of UCNPs. Such a hetero-assembled DNA-AuNP/UCNP system maintains both plasmonic resonance of AuNPs and fluorescent properties of UCNPs, allowing targeted dual-modality imaging of cancer cells using an aptamer.

SUBMITTER: Li LL

PROVIDER: S-EPMC4677663 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures.

Li Le-Le LL Lu Yi Y

Journal of the American Chemical Society 20150417 16

We report a novel strategy for regiospecific hetero-assembly of DNA-modified gold nanoparticles (DNA-AuNPs) onto upconversion nanoparticles (UCNPs) into hybrid lab-on-a-particle systems. The DNA-AuNPs have been assembled onto the hexagonal plate-like UCNPs with well-regulated stoichiometry and controlled organization onto the different facets of UCNP, forming various addressable superstructures. The fine-tuning of stoichiometry and organization is realized by biorecognition specificity of DNA to ...[more]

PMID: 25853565

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