Ontology highlight
ABSTRACT:
SUBMITTER: Gamarra D
PROVIDER: S-EPMC4678069 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Gamarra David D Elcoroaristizabal Xabier X Fernández-Martínez Manuel M de Pancorbo Marian M MM
Disease markers 20151201
Oxidative stress plays an important part in amnestic mild cognitive impairment (aMCI), the prodromal phase of Alzheimer's disease (AD). Recent evidence shows that polymorphisms in the SOD2 gene affect the elimination of the reactive oxygen species (ROS) generated in mitochondria. The aim of this study was to determine whether the functional rs4880 SNP in the SOD2 gene is a risk factor associated with aMCI and sporadic AD. 216 subjects with aMCI, 355 with AD, and 245 controls have been studied. T ...[more]