Dataset Information

Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis.

ABSTRACT:

Objective

To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human.

Methods

A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nondiabetic adults.

Results

A total of nine eligible studies with twelve comparisons were included for the final meta-analysis. Circulating betatrophin levels in T2DM patients were higher than those in the nondiabetic controls (random-effect SMD 0.53; 95% CI 0.13 to 0.94; P = 0.010). In the subgroup of nonobese population but not the obese population, the overall betatrophin level in T2DM patients was much higher than that in the nondiabetic controls (nonobese: random-effect SMD, 0.82; 95% CI 0.42 to 1.21; P < 0.001; obese: random-effect SMD, -0.39; 95% CI, -0.95 to 0.18; P = 0.18). Metaregression indicated that body mass index of T2DM patients was associated with mean difference of betatrophin level between T2DM and nondiabetic adults (slope, -578.8; t = -2.7; P = 0.02).

Conclusion

Based on the findings of our meta-analysis, circulating betatrophin level of T2DM patients is higher than that of nondiabetic adults in the nonobese population, but not in the obese population.

SUBMITTER: Li S

PROVIDER: S-EPMC4678092 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis.

Li Sheyu S Liu Dan D Li Ling L Li Yun Y Li Qianrui Q An Zhenmei Z Sun Xin X Tian Haoming H

Journal of diabetes research 20151201

<h4>Objective</h4>To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human.<h4>Methods</h4>A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nondiabetic adults.<h4>Results</h4>A total of nine eligible studies with twelve comparisons were included for the final meta-analysis. Circulating betatrophin levels in T ...[more]

PMID: 26697500

Similar Datasets

Project description:Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder worldwide. Because of population aging and increasing trends toward obesity and sedentary lifestyles, the number of affected individuals is increasing at worrisome rates. While both environmental and genetic factors are known to contribute to the development of T2DM, continuous research is needed to identify specific biomarkers that could aid both in prevention of the disease and development of newer therapeutic options. Circulating miRNAs are considered as potential biomarkers because they are stable and resistant to degradation by blood RNAses and are modified under different pathophysiological conditions. In this study we carried out a systematic electronic search on PubMed to retrieve all articles that have investigated circulating miRNAs for diagnosing obesity andT2DM in human. We also included lifestyle intervention studies known to be highly effective in delaying onset of diabetes, and studies analyzing the effect of bariatric surgery and anti-diabetic treatment. A total of 26 studies were enrolled in the global meta-analysis. Candidate miRNAs were defined as those reported in at least 2 studies with same direction of differential expression. Ten miRNAs altered in blood of patients suffering fromT2DM were identified (increased: miR-320a, miR-142-3p, miR-222, miR-29a, miR-27a, miR-375; decreased: miR-197, miR-20b, miR-17, miR-652) and 7 miRNAs in blood of obese subjects were identified (increased: miR-142-3p, miR-140-5p, miR-222; decreased:miR-21-5p, miR-221-3p, miR-125-5p, mir-103-5p). Both obese and T2DM patients had elevated concentrations of miR-142-3p and miR-222. MiRNAs target genes were predicted and their cellular functions are discussed in relation with the pathologies. Although a significant number of studies were taken into account in this review, we found a strong discrepancy between miRNA detection and quantification indicating that many of pre-analytical variables have yet to be normalized. Pre-analytical and analytical challenges are also discussed.

Dataset Information

Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis.

Objective

Methods

Results

Conclusion

Publications

Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis.

Similar Datasets

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