Ontology highlight
ABSTRACT:
SUBMITTER: Richardson K
PROVIDER: S-EPMC4678117 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Richardson Katie K Livieratos Achilleas A Dumbill Richard R Hughes Steven S Ang Gauri G Smith David A DA Morris Lauren L Brown Laurence A LA Peirson Stuart N SN Platt Frances M FM Davies Kay E KE Oliver Peter L PL
Behavioural brain research 20151020
Sleep and circadian rhythm disruption is frequently associated with neurodegenerative disease, yet it is unclear how the specific pathology in these disorders leads to abnormal rest/activity profiles. To investigate whether the pathological features of lysosomal storage disorders (LSDs) influence the core molecular clock or the circadian behavioural abnormalities reported in some patients, we examined mouse models of Niemann-Pick Type-C (Npc1 mutant, Npc1(nih)) and Sandhoff (Hexb knockout, Hexb( ...[more]