Ontology highlight
ABSTRACT:
SUBMITTER: Catenacci DV
PROVIDER: S-EPMC4678179 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Catenacci Daniel V T DV Junttila Melissa R MR Karrison Theodore T Bahary Nathan N Horiba Margit N MN Nattam Sreenivasa R SR Marsh Robert R Wallace James J Kozloff Mark M Rajdev Lakshmi L Cohen Deirdre D Wade James J Sleckman Bethany B Lenz Heinz-Josef HJ Stiff Patrick P Kumar Pankaj P Xu Peng P Henderson Les L Takebe Naoko N Salgia Ravi R Wang Xi X Stadler Walter M WM de Sauvage Frederic J FJ Kindler Hedy L HL
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20151102 36
<h4>Purpose</h4>Sonic hedgehog (SHH), an activating ligand of smoothened (SMO), is overexpressed in > 70% of pancreatic cancers (PCs). We investigated the impact of vismodegib, an SHH antagonist, plus gemcitabine (GV) or gemcitabine plus placebo (GP) in a multicenter phase Ib/randomized phase II trial and preclinical PC models.<h4>Patients and methods</h4>Patients with PC not amenable to curative therapy who had received no prior therapy for metastatic disease and had Karnofsky performance score ...[more]