Ontology highlight
ABSTRACT:
SUBMITTER: Goodfellow PJ
PROVIDER: S-EPMC4678181 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Goodfellow Paul J PJ Billingsley Caroline C CC Lankes Heather A HA Ali Shamshad S Cohn David E DE Broaddus Russell J RJ Ramirez Nilsa N Pritchard Colin C CC Hampel Heather H Chassen Alexis S AS Simmons Luke V LV Schmidt Amy P AP Gao Feng F Brinton Louise A LA Backes Floor F Landrum Lisa M LM Geller Melissa A MA DiSilvestro Paul A PA Pearl Michael L ML Lele Shashikant B SB Powell Matthew A MA Zaino Richard J RJ Mutch David D
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20151109 36
<h4>Purpose</h4>The best screening practice for Lynch syndrome (LS) in endometrial cancer (EC) remains unknown. We sought to determine whether tumor microsatellite instability (MSI) typing along with immunohistochemistry (IHC) and MLH1 methylation analysis can help identify women with LS.<h4>Patients and methods</h4>ECs from GOG210 patients were assessed for MSI, MLH1 methylation, and mismatch repair (MMR) protein expression. Each tumor was classified as having normal MMR, defective MMR associat ...[more]