Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.
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ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC4678883 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.
Wang Qiang Q Li Miaoxin M Yang Zhenxing Z Hu Xun X Wu Hei-Man HM Ni Peiyan P Ren Hongyan H Deng Wei W Li Mingli M Ma Xiaohong X Guo Wanjun W Zhao Liansheng L Wang Yingcheng Y Xiang Bo B Lei Wei W Sham Pak C PC Li Tao T
Scientific reports 20151215
Schizophrenia is a heritable, heterogeneous common psychiatric disorder. In this study, we evaluated the hypothesis that de novo variants (DNVs) contribute to the pathogenesis of schizophrenia. We performed exome sequencing in Chinese patients (N = 45) with schizophrenia and their unaffected parents (N = 90). Forty genes were found to contain DNVs. These genes had enriched transcriptional co-expression profile in prenatal frontal cortex (Bonferroni corrected p < 9.1 × 10(-3)), and in prenatal te ...[more]
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