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Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.

ABSTRACT: Schizophrenia is a heritable, heterogeneous common psychiatric disorder. In this study, we evaluated the hypothesis that de novo variants (DNVs) contribute to the pathogenesis of schizophrenia. We performed exome sequencing in Chinese patients (N?=?45) with schizophrenia and their unaffected parents (N?=?90). Forty genes were found to contain DNVs. These genes had enriched transcriptional co-expression profile in prenatal frontal cortex (Bonferroni corrected p?

SUBMITTER: Wang Q

PROVIDER: S-EPMC4678883 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.

Wang Qiang Q Li Miaoxin M Yang Zhenxing Z Hu Xun X Wu Hei-Man HM Ni Peiyan P Ren Hongyan H Deng Wei W Li Mingli M Ma Xiaohong X Guo Wanjun W Zhao Liansheng L Wang Yingcheng Y Xiang Bo B Lei Wei W Sham Pak C PC Li Tao T

Scientific reports 20151215

Schizophrenia is a heritable, heterogeneous common psychiatric disorder. In this study, we evaluated the hypothesis that de novo variants (DNVs) contribute to the pathogenesis of schizophrenia. We performed exome sequencing in Chinese patients (N = 45) with schizophrenia and their unaffected parents (N = 90). Forty genes were found to contain DNVs. These genes had enriched transcriptional co-expression profile in prenatal frontal cortex (Bonferroni corrected p < 9.1 × 10(-3)), and in prenatal te ...[more]

PMID: 26666178

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