Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China.

ABSTRACT: The role of FEN1 genetic variants on gallstone and gallbladder cancer susceptibility is unknown. FEN1 SNPs were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method in blood samples from 341 gallbladder cancer patients and 339 healthy controls. The distribution of FEN1-69G?>?A genotypes among controls (AA, 20.6%; GA, 47.2% and GG 32.2%) was significantly different from that among gallbladder cancer cases (AA, 11.1%; GA, 48.1% and GG, 40.8%), significantly increased association with gallbladder cancer was observed for subjects with both the FEN1-69G?>?A GA (OR?=?1.73, 95% CI?=?1.01-2.63) and the FEN1-69G?>?A GG (OR?=?2.29, 95% CI?=?1.31-3.9). The distribution of FEN1 -4150T genotypes among controls (TT, 21.8%;GT, 49.3% and GG 28.9%) was significantly different from that among gallbladder cancer cases (TT, 12.9%; GT, 48.4% and GG 38.7%), significantly increased association with gallbladder cancer was observed for subjects with both the FEN1-4150T GT(OR?=?1.93, 95% CI?=?1.04-2.91) and the FEN1-4150T GG(OR?=?2.56, 95% CI?=?1.37-5.39). A significant trend towards increased association with gallbladder cancer was observed with potentially higher-risk FEN1-69G?>?A genotypes (P??T (P?

SUBMITTER: Jiao X 

PROVIDER: S-EPMC4678911 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature