Ontology highlight
ABSTRACT:
SUBMITTER: Kurnellas MP
PROVIDER: S-EPMC4679000 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Kurnellas Michael Phillip MP Ghosn Eliver Eid Bou EE Schartner Jill M JM Baker Jeanette J Rothbard Jesse J JJ Negrin Robert S RS Herzenberg Leonore A LA Fathman C Garrison CG Steinman Lawrence L Rothbard Jonathan B JB
Proceedings of the National Academy of Sciences of the United States of America 20151130 49
Amyloid fibrils composed of peptides as short as six amino acids are therapeutic in experimental autoimmune encephalomyelitis (EAE), reducing paralysis and inflammation, while inducing several pathways of immune suppression. Intraperitoneal injection of fibrils selectively activates B-1a lymphocytes and two populations of resident macrophages (MΦs), increasing IL-10 production, and triggering their exodus from the peritoneum. The importance of IL-10-producing B-1a cells in this effective therapy ...[more]