Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization.

ABSTRACT:

Background

In human subjects, allergen tolerance has been observed after high-dose allergen exposure or after completed allergen immunotherapy, which is related to the accumulation of anti-inflammatory IgG4. However, the specific T-cell response that leads to IgG4 induction during chronic allergen exposure remains poorly understood.

Objective

We sought to evaluate the relationship between cat allergen-specific T-cell frequency, cat allergen-specific IgE and IgG4 titers, and clinical status in adults with cat allergy with and without cat ownership and the cellular mechanism by which IgG4 is produced.

Methods

Fel d 1-, Fel d 4-, Fel d 7-, and Fel d 8-specific T-cell responses were characterized by CD154 expression after antigen stimulation.

Results

In allergic su

SUBMITTER: Renand A 

PROVIDER: S-EPMC4679456 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature