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Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging.

ABSTRACT: Detection of protein expression by MRI requires a high payload of Gd(III) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(III) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

SUBMITTER: Vistain LF

PROVIDER: S-EPMC4679476 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging.

Vistain Luke F LF Rotz Matthew W MW Rathore Richa R Preslar Adam T AT Meade Thomas J TJ

Chemical communications (Cambridge, England) 20160101 1

Detection of protein expression by MRI requires a high payload of Gd(III) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(III) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells. ...[more]

PMID: 26505558

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