Evidence of perturbations of the cytokine network in preterm labor.

ABSTRACT:

Objective

Intraamniotic inflammation/infection is the only mechanism of disease with persuasive evidence of causality for spontaneous preterm labor/delivery. Previous studies about the behavior of cytokines in preterm labor have been largely based on the analysis of the behavior of each protein independently. Emerging evidence indicates that the study of biologic networks can provide insight into the pathobiology of disease and improve biomarker discovery. The goal of this study was to characterize the inflammatory-related protein network in the amniotic fluid of patients with preterm labor.

Study design

A retrospective cohort study was conducted that included women with singleton pregnancies who had spontaneous preterm labor and intact membranes (n = 135). These patients we

SUBMITTER: Romero R 

PROVIDER: S-EPMC4679519 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature