Ontology highlight
ABSTRACT:
SUBMITTER: Ciomperlik JJ
PROVIDER: S-EPMC4679524 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Ciomperlik Jessica J JJ Basta Holly A HA Palmenberg Ann C AC
Virology 20151019
Cardiovirus Leader proteins (LX) inhibit cellular nucleocytoplasmic trafficking by directing host kinases to phosphorylate Phe/Gly-containing nuclear pore proteins (Nups). Resolution of the Mengovirus LM structure bound to Ran GTPase, suggested this complex would further recruit specific exportins (karyopherins), which in turn mediate kinase selection. Pull-down experiments and recombinant complex reconstitution now confirm that Crm1 and CAS exportins form stable dimeric complexes with encephalo ...[more]