Contactin 1 as a potential biomarker promotes cell proliferation and invasion in thyroid cancer.
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ABSTRACT:
SUBMITTER: Shi K
PROVIDER: S-EPMC4680379 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Contactin 1 as a potential biomarker promotes cell proliferation and invasion in thyroid cancer.
Shi Kaiyuan K Xu Dong D Yang Chen C Wang Liping L Pan Weiyun W Zheng Chuanming C Fan Linyin L
International journal of clinical and experimental pathology 20151001 10
Contactin 1 (CNTN1) as a member of the immunoglobulin superfamily plays important role in the development of nervous system. Recent studies find that elevated CNTN1 can promote the metastasis of cancer. However, the expression and function of CNTN1 in thyroid cancer are still unknown. Here, we firstly find CNTN1 is a new gene which can be regulated by RET/PTC3 (Ret proto-oncogene and Ret-activating protein ELE1) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer. B ...[more]
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