Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC4680857 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Zhang Heng H Han Min-Jie MJ Tao Jianli J Ye Zhao-Yang ZY Du Xiao-Xia XX Deng Ming-Jing MJ Zhang Xiao-Yan XY Li Lan-Fen LF Jiang Zheng-Fan ZF Su Xiao-Dong XD
Scientific reports 20151216
Cyclic dinucleotides (CDNs) and antitumor/antiviral agents (DMXAA and CMA) trigger STING-dependent innate immunity activation. Accumulative evidences have showed that DMXAA and CMA selectively activate mouse, but not human STING signaling. The mechanism underlying this species selectivity remains poorly understood. In this report, we have shown that human and rat STINGs display more similar signaling profiles toward DMXAA and CMA than that of human and mouse STINGs, suggesting that rat is more s ...[more]