Ontology highlight
ABSTRACT:
SUBMITTER: Milech N
PROVIDER: S-EPMC4680871 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Milech Nadia N Longville Brooke A C BA Cunningham Paula T PT Scobie Marie N MN Bogdawa Heique M HM Winslow Scott S Anastasas Mark M Connor Theresa T Ong Ferrer F Stone Shane R SR Kerfoot Maria M Heinrich Tatjana T Kroeger Karen M KM Tan Yew-Foon YF Hoffmann Katrin K Thomas Wayne R WR Watt Paul M PM Hopkins Richard M RM
Scientific reports 20151216
Efficient cargo uptake is essential for cell-penetrating peptide (CPP) therapeutics, which deliver widely diverse cargoes by exploiting natural cell processes to penetrate the cell's membranes. Yet most current CPP activity assays are hampered by limitations in assessing uptake, including confounding effects of conjugated fluorophores or ligands, indirect read-outs requiring secondary processing, and difficulty in discriminating internalization from endosomally trapped cargo. Split-complementati ...[more]