Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez S
PROVIDER: S-EPMC4681116 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Rodriguez Santiago S Gaunt Tom R TR Guo Yiran Y Zheng Jie J Barnes Michael R MR Tang Weihang W Danish Fazal F Johnson Andrew A Castillo Berta A BA Li Yun R YR Hakonarson Hakon H Buxbaum Sarah G SG Palmer Tom T Tsai Michael Y MY Lange Leslie A LA Ebrahim Shah S Davey Smith George G Lawlor Debbie A DA Folsom Aaron R AR Hoogeveen Ron R Reiner Alex A Keating Brendan B Day Ian N M IN
European journal of human genetics : EJHG 20150429 1
Gallbladder disease (GBD) has an overall prevalence of 10-40% depending on factors such as age, gender, population, obesity and diabetes, and represents a major economic burden. Although gallstones are composed of cholesterol by-products and are associated with obesity, presumed causal pathways remain unproven, although BMI reduction is typically recommended. We performed genetic studies to discover candidate genes and define pathways involved in GBD. We genotyped 15,241 women of European ancest ...[more]