Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.
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ABSTRACT:
SUBMITTER: Etxeberria A
PROVIDER: S-EPMC4681435 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.
Etxeberria Ainhoa A Mangin Jean-Marie JM Aguirre Adan A Gallo Vittorio V
Nature neuroscience 20100221 3
We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that oc ...[more]
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