Ontology highlight
ABSTRACT:
SUBMITTER: Vasudevan D
PROVIDER: S-EPMC4681644 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Vasudevan Divya D Hickok Jason R JR Bovee Rhea C RC Pham Vy V Mantell Lin L LL Bahroos Neil N Kanabar Pinal P Cao Xing-Jun XJ Maienschein-Cline Mark M Garcia Benjamin A BA Thomas Douglas D DD
Cancer research 20151105 24
Altered nitric oxide (•NO) metabolism underlies cancer pathology, but mechanisms explaining many •NO-associated phenotypes remain unclear. We have found that cellular exposure to •NO changes histone posttranslational modifications (PTM) by directly inhibiting the catalytic activity of JmjC-domain containing histone demethylases. Herein, we describe how •NO exposure links modulation of histone PTMs to gene expression changes that promote oncogenesis. Through high-resolution mass spectrometry, we ...[more]