Large-scale extraction of gene interactions from full-text literature using DeepDive.

ABSTRACT: MOTIVATION:A complete repository of gene-gene interactions is key for understanding cellular processes, human disease and drug response. These gene-gene interactions include both protein-protein interactions and transcription factor interactions. The majority of known interactions are found in the biomedical literature. Interaction databases, such as BioGRID and ChEA, annotate these gene-gene interactions; however, curation becomes difficult as the literature grows exponentially. DeepDive is a trained system for extracting information from a variety of sources, including text. In this work, we used DeepDive to extract both protein-protein and transcription factor interactions from over 100,000 full-text PLOS articles. METHODS:We built an extractor for gene-gene interactions that identified

SUBMITTER: Mallory EK 

PROVIDER: S-EPMC4681986 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature