Ontology highlight
ABSTRACT:
SUBMITTER: Juliandi B
PROVIDER: S-EPMC4682151 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Juliandi Berry B Tanemura Kentaro K Igarashi Katsuhide K Tominaga Takashi T Furukawa Yusuke Y Otsuka Maky M Moriyama Noriko N Ikegami Daigo D Abematsu Masahiko M Sanosaka Tsukasa T Tsujimura Keita K Narita Minoru M Kanno Jun J Nakashima Kinichi K
Stem cell reports 20151119 6
Prenatal exposure to valproic acid (VPA), an established antiepileptic drug, has been reported to impair postnatal cognitive function in children born to VPA-treated epileptic mothers. However, how these defects arise and how they can be overcome remain unknown. Using mice, we found that comparable postnatal cognitive functional impairment is very likely correlated to the untimely enhancement of embryonic neurogenesis, which led to depletion of the neural precursor cell pool and consequently a d ...[more]