Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC4682171 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Wang Zhiwei Z Dai Xiangpeng X Zhong Jiateng J Inuzuka Hiroyuki H Wan Lixin L Li Xiaoning X Wang Lixia L Ye Xiantao X Sun Liankun L Gao Daming D Zou Lee L Wei Wenyi W
Nature communications 20151215
The Set8/PR-Set7/KMT5a methyltransferase plays critical roles in governing transcriptional regulation, cell cycle progression and tumorigenesis. Although CRL4(Cdt2) was reported to regulate Set8 stability, deleting the PIP motif only led to partial resistance to ultraviolet-induced degradation of Set8, indicating the existence of additional E3 ligase(s) controlling Set8 stability. Furthermore, it remains largely undefined how DNA damage-induced kinase cascades trigger the timely destruction of S ...[more]