Ontology highlight
ABSTRACT:
SUBMITTER: Ben-Gedalya T
PROVIDER: S-EPMC4682640 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Ben-Gedalya Tziona T Moll Lorna L Bejerano-Sagie Michal M Frere Samuel S Cabral Wayne A WA Friedmann-Morvinski Dinorah D Slutsky Inna I Burstyn-Cohen Tal T Marini Joan C JC Cohen Ehud E
The EMBO journal 20151005 22
Do different neurodegenerative maladies emanate from the failure of a mutual protein folding mechanism? We have addressed this question by comparing mutational patterns that are linked to the manifestation of distinct neurodegenerative disorders and identified similar neurodegeneration-linked proline substitutions in the prion protein and in presenilin 1 that underlie the development of a prion disorder and of familial Alzheimer's disease (fAD), respectively. These substitutions were found to pr ...[more]