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Eukaryote-specific extensions in ribosomal proteins of the small subunit: Structure and function.

ABSTRACT: High-resolution structures of yeast ribosomes have improved our understanding of the architecture and organization of eukaryotic rRNA and proteins, as well as eukaryote-specific extensions present in some conserved ribosomal proteins. Despite this progress, assignment of specific functions to individual proteins and/or eukaryote-specific protein extensions remains challenging. It has been suggested that eukaryote-specific extensions of conserved proteins from the small ribosomal subunit may facilitate eukaryote-specific reactions in the initiation phase of protein synthesis. This review summarizes emerging data describing the structural and functional significance of eukaryote-specific extensions of conserved small ribosomal subunit proteins, particularly their possible roles in recruitment and spatial organization of eukaryote-specific initiation factors.

SUBMITTER: Ghosh A

PROVIDER: S-EPMC4682806 | biostudies-literature | 2015 Jan-Jun

REPOSITORIES: biostudies-literature

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Eukaryote-specific extensions in ribosomal proteins of the small subunit: Structure and function.

Ghosh Arnab A Komar Anton A AA

Translation (Austin, Tex.) 20150101 1

High-resolution structures of yeast ribosomes have improved our understanding of the architecture and organization of eukaryotic rRNA and proteins, as well as eukaryote-specific extensions present in some conserved ribosomal proteins. Despite this progress, assignment of specific functions to individual proteins and/or eukaryote-specific protein extensions remains challenging. It has been suggested that eukaryote-specific extensions of conserved proteins from the small ribosomal subunit may faci ...[more]

PMID: 26779416

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