Ontology highlight
ABSTRACT:
SUBMITTER: Yabe R
PROVIDER: S-EPMC4683032 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yabe Ryotaro R Miura Akane A Usui Tatsuya T Mudrak Ingrid I Ogris Egon E Ohama Takashi T Sato Koichi K
PloS one 20151217 12
Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways. Protein phosphatase methyl esterase (PME-1) catalyzes specifically the demethylation of the C-terminal Leu309 residue of PP2A catalytic subunit (PP2Ac). It has been shown that PME-1 affects the activity of PP2A by demethylating PP2Ac, but also by directly binding to the phosphatase active site, suggesting loss of PME-1 i ...[more]