Ontology highlight
ABSTRACT:
SUBMITTER: Zylbertal A
PROVIDER: S-EPMC4684409 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Zylbertal Asaph A Kahan Anat A Ben-Shaul Yoram Y Yarom Yosef Y Wagner Shlomo S
PLoS biology 20151216 12
Persistent activity has been reported in many brain areas and is hypothesized to mediate working memory and emotional brain states and to rely upon network or biophysical feedback. Here, we demonstrate a novel mechanism by which persistent neuronal activity can be generated without feedback, relying instead on the slow removal of Na+ from neurons following bursts of activity. We show that mitral cells in the accessory olfactory bulb (AOB), which plays a major role in mammalian social behavior, m ...[more]