Novel remodeling of the mouse heart mitochondrial proteome in response to acute insulin stimulation.
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ABSTRACT:
SUBMITTER: Pedersen BA
PROVIDER: S-EPMC4684478 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Novel remodeling of the mouse heart mitochondrial proteome in response to acute insulin stimulation.
Pedersen B A BA Yazdi P G PG Taylor J F JF Khattab O S OS Chen Y-H YH Chen Y Y Wang P H PH
Nutrition, metabolism, and cardiovascular diseases : NMCD 20151022 12
<h4>Background and aim</h4>Mitochondrial dysfunction contributes to the pathophysiology of diabetic cardiomyopathy. The aim of this study was to investigate the acute changes in the mitochondrial proteome in response to insulin stimulation.<h4>Methods and results</h4>Cardiac mitochondria from C57BL/6 mice after insulin stimulation were analyzed using two-dimensional fluorescence difference gel electrophoresis. MALDI-TOF MS/MS was utilized to identify differences. Two enzymes involved in metaboli ...[more]
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