Ontology highlight
ABSTRACT:
SUBMITTER: Brahma B
PROVIDER: S-EPMC4684500 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Brahma Biswajit B Patra Mahesh Chandra MC Karri Satyanagalakshmi S Chopra Meenu M Mishra Purusottam P De Bidhan Chandra BC Kumar Sushil S Mahanty Sourav S Thakur Kiran K Poluri Krishna Mohan KM Datta Tirtha Kumar TK De Sachinandan S
PloS one 20151216 12
Cathelicidins are an ancient class of antimicrobial peptides (AMPs) with broad spectrum bactericidal activities. In this study, we investigated the diversity and biological activity of cathelicidins of buffalo, a species known for its disease resistance. A series of new homologs of cathelicidin4 (CATHL4), which were structurally diverse in their antimicrobial domain, was identified in buffalo. AMPs of newly identified buffalo CATHL4s (buCATHL4s) displayed potent antimicrobial activity against se ...[more]