Ontology highlight
ABSTRACT:
SUBMITTER: Zboray L
PROVIDER: S-EPMC4684905 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Zboray Lori L Pluciennik Anna A Curtis Dana D Liu Yuhong Y Berman-Booty Lisa D LD Orr Christopher C Kesler Cristina T CT Berger Tamar T Gioeli Daniel D Paschal Bryce M BM Merry Diane E DE
Cell reports 20151207 10
Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by a polyglutamine expansion in the androgen receptor (AR) and is associated with misfolding and aggregation of the mutant AR. We investigated the role of an interdomain interaction between the amino (N)-terminal FxxLF motif and carboxyl (C)-terminal AF-2 domain in a mouse model of SBMA. Male transgenic mice expressing polyQ-expanded AR with a mutation in the FxxLF motif (F23A) to prevent the N/C interaction displaye ...[more]