Ontology highlight
ABSTRACT:
SUBMITTER: Englund E
PROVIDER: S-EPMC4685428 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Englund Elias E Andersen-Ranberg Johan J Miao Rui R Hamberger Björn B Lindberg Pia P
ACS synthetic biology 20150713 12
Forskolin is a high value diterpenoid with a broad range of pharmaceutical applications, naturally found in root bark of the plant Coleus forskohlii. Because of its complex molecular structure, chemical synthesis of forskolin is not commercially attractive. Hence, the labor and resource intensive extraction and purification from C. forskohlii plants remains the current source of the compound. We have engineered the unicellular cyanobacterium Synechocystis sp. PCC 6803 to produce the forskolin pr ...[more]