In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana.

ABSTRACT: To assess associations between in-utero triple antiretrovirals (cART) versus zidovudine (ZDV) monotherapy exposure and growth among HIV-uninfected children of HIV-infected women in Botswana.Secondary retrospective data analysis from two randomized intervention trials of mother-to-child HIV transmission prevention.The Mashi and Mma Bana studies enrolled HIV-infected pregnant women, following their children through 24 months of age. This analysis includes singleton, full-term, HIV-exposed uninfected children. Mothers received cART or ZDV at least 2 weeks predelivery, and breastfed up to 6 months. Weight-for-age (WAZ), length-for-age (LAZ) and weight-for-length (WLZ) z-scores were derived. Mean z-scores were compared by exposure group at 24 months (t-test, linear regression).Of 819 children, 303 were ZDV- and 516 cART-exposed in utero. Maternal median enrolment CD4 was higher among ZDV versus cART-treated mothers (393 versus 324?cells/?l; P?

SUBMITTER: Powis KM 

PROVIDER: S-EPMC4685731 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature