Ontology highlight
ABSTRACT:
SUBMITTER: Di Mola A
PROVIDER: S-EPMC4685908 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Di Mola Antonia A Tiffner Maximilian M Scorzelli Francesco F Palombi Laura L Filosa Rosanna R De Caprariis Paolo P Waser Mario M Massa Antonio A
Beilstein journal of organic chemistry 20151215
New bifunctional chiral ammonium salts were investigated in an asymmetric cascade synthesis of a key building block for a variety of biologically relevant isoindolinones. With this chiral compound in hand, the development of further transformations allowed for the synthesis of diverse derivatives of high pharmaceutical value, such as the Belliotti (S)-PD172938 and arylated analogues with hypnotic sedative activity, obtained in good overall total yield (50%) and high enantiomeric purity (95% ee). ...[more]