Ontology highlight
ABSTRACT:
SUBMITTER: Lesma G
PROVIDER: S-EPMC4685954 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Lesma Giordano G Bassanini Ivan I Bortolozzi Roberta R Colletto Chiara C Bai Ruoli R Hamel Ernest E Meneghetti Fiorella F Rainoldi Giulia G Stucchi Mattia M Sacchetti Alessandro A Silvani Alessandra A Viola Giampietro G
Organic & biomolecular chemistry 20151015 48
A small family of structural analogues of the antimitotic tripeptides, hemiasterlins, have been designed and synthesized as potential inhibitors of tubulin polymerization. The effectiveness of a multicomponent approach was fully demonstrated by applying complementary versions of the isocyanide-based Ugi reaction. Compounds strictly related to the lead natural products, as well as more extensively modified analogues, have been synthesized in a concise and convergent manner. In some cases, biologi ...[more]