Ontology highlight
ABSTRACT:
SUBMITTER: Nanya M
PROVIDER: S-EPMC4686171 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Nanya Mai M Sato Masaki M Tanimoto Kousuke K Tozuka Minoru M Mizutani Shuki S Takagi Masatoshi M
PloS one 20151211 12
Etoposide, a topoisomerase 2 (TOP2) inhibitor, is associated with the development of KMT2A (MLL)-rearranged infant leukemia. An epidemiological study suggested that in utero exposure to TOP2 inhibitors may be involved in generation of KMT2A (MLL) rearrangement. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model. Fetal liver hematopoietic stem cells were more susceptible to et ...[more]