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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

ABSTRACT: Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1?s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

SUBMITTER: Soler Artigas M 

PROVIDER: S-EPMC4686825 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Soler Artigas María M   Wain Louise V LV   Miller Suzanne S   Kheirallah Abdul Kader AK   Huffman Jennifer E JE   Ntalla Ioanna I   Shrine Nick N   Obeidat Ma'en M   Trochet Holly H   McArdle Wendy L WL   Alves Alexessander Couto AC   Hui Jennie J   Zhao Jing Hua JH   Joshi Peter K PK   Teumer Alexander A   Albrecht Eva E   Imboden Medea M   Rawal Rajesh R   Lopez Lorna M LM   Marten Jonathan J   Enroth Stefan S   Surakka Ida I   Polasek Ozren O   Lyytikäinen Leo-Pekka LP   Granell Raquel R   Hysi Pirro G PG   Flexeder Claudia C   Mahajan Anubha A   Beilby John J   Bossé Yohan Y   Brandsma Corry-Anke CA   Campbell Harry H   Gieger Christian C   Gläser Sven S   González Juan R JR   Grallert Harald H   Hammond Chris J CJ   Harris Sarah E SE   Hartikainen Anna-Liisa AL   Heliövaara Markku M   Henderson John J   Hocking Lynne L   Horikoshi Momoko M   Hutri-Kähönen Nina N   Ingelsson Erik E   Johansson Åsa Å   Kemp John P JP   Kolcic Ivana I   Kumar Ashish A   Lind Lars L   Melén Erik E   Musk Arthur W AW   Navarro Pau P   Nickle David C DC   Padmanabhan Sandosh S   Raitakari Olli T OT   Ried Janina S JS   Ripatti Samuli S   Schulz Holger H   Scott Robert A RA   Sin Don D DD   Starr John M JM   Viñuela Ana A   Völzke Henry H   Wild Sarah H SH   Wright Alan F AF   Zemunik Tatijana T   Jarvis Deborah L DL   Spector Tim D TD   Evans David M DM   Lehtimäki Terho T   Vitart Veronique V   Kähönen Mika M   Gyllensten Ulf U   Rudan Igor I   Deary Ian J IJ   Karrasch Stefan S   Probst-Hensch Nicole M NM   Heinrich Joachim J   Stubbe Beate B   Wilson James F JF   Wareham Nicholas J NJ   James Alan L AL   Morris Andrew P AP   Jarvelin Marjo-Riitta MR   Hayward Caroline C   Sayers Ian I   Strachan David P DP   Hall Ian P IP   Tobin Martin D MD  

Nature communications 20151204

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN  ...[more]

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