Ontology highlight
ABSTRACT:
SUBMITTER: Lawson MA
PROVIDER: S-EPMC4686867 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Lawson Michelle A MA McDonald Michelle M MM Kovacic Natasa N Hua Khoo Weng W Terry Rachael L RL Down Jenny J Kaplan Warren W Paton-Hough Julia J Fellows Clair C Pettitt Jessica A JA Neil Dear T T Van Valckenborgh Els E Baldock Paul A PA Rogers Michael J MJ Eaton Colby L CL Vanderkerken Karin K Pettit Allison R AR Quinn Julian M W JM Zannettino Andrew C W AC Phan Tri Giang TG Croucher Peter I PI
Nature communications 20151203
Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the niche, and how it exerts cell-extrinsic control over myeloma cell dormancy and reactivation. In this study, we track individual myeloma cells by intravital imaging as they colonize the endosteal nich ...[more]