Ontology highlight
ABSTRACT:
SUBMITTER: Kessler M
PROVIDER: S-EPMC4686873 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kessler Mirjana M Hoffmann Karen K Brinkmann Volker V Thieck Oliver O Jackisch Susan S Toelle Benjamin B Berger Hilmar H Mollenkopf Hans-Joachim HJ Mangler Mandy M Sehouli Jalid J Fotopoulou Christina C Meyer Thomas F TF
Nature communications 20151208
The epithelial lining of the fallopian tube is of critical importance for human reproduction and has been implicated as a site of origin of high-grade serous ovarian cancer. Here we report on the establishment of long-term, stable 3D organoid cultures from human fallopian tubes, indicative of the presence of adult stem cells. We show that single epithelial stem cells in vitro can give rise to differentiated organoids containing ciliated and secretory cells. Continuous growth and differentiation ...[more]