Ontology highlight
ABSTRACT:
SUBMITTER: Ribeiro M
PROVIDER: S-EPMC4686914 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Ribeiro Miguel M Nunes Fernando M FM Guedes Sofia S Domingues Pedro P Silva Amélia M AM Carrillo Jose Maria JM Rodriguez-Quijano Marta M Branlard Gérard G Igrejas Gilberto G
Scientific reports 20151222
Protein engineering of gluten, the exogenous effector in celiac disease, seeking its detoxification by selective chemical modification of toxic epitopes is a very attractive strategy and promising technology when compared to pharmacological treatment or genetic engineering of wheat. Here we present a simple and efficient chemo-enzymatic methodology that decreases celiac disease toxic epitopes of gluten proteins improving its technological value through microbial transglutaminase-mediated transam ...[more]