Coherent Motion of Monolayer Sheets under Confinement and Its Pathological Implications.

ABSTRACT: Coherent angular rotation of epithelial cells is thought to contribute to many vital physiological processes including tissue morphogenesis and glandular formation. However, factors regulating this motion, and the implications of this motion if perturbed, remain incompletely understood. In the current study, we address these questions using a cell-center based model in which cells are polarized, motile, and interact with the neighboring cells via harmonic forces. We demonstrate that, a simple evolution rule in which the polarization of any cell tends to orient with its velocity vector can induce coherent motion in geometrically confined environments. In addition to recapitulating coherent rotational motion observed in experiments, our results also show the presence of radial movements and

SUBMITTER: Soumya SS 

PROVIDER: S-EPMC4686989 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature