Ontology highlight
ABSTRACT:
SUBMITTER: Kruger A
PROVIDER: S-EPMC4687425 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Krüger Anne A Oldenburg Marina M Chebrolu Chiranjeevi C Beisser Daniela D Kolter Julia J Sigmund Anna M AM Steinmann Jörg J Schäfer Simon S Hochrein Hubertus H Rahmann Sven S Wagner Hermann H Henneke Philipp P Hornung Veit V Buer Jan J Kirschning Carsten J CJ
EMBO reports 20151106 12
Toll-like receptor (TLR) 13 and TLR2 are the major sensors of Gram-positive bacteria in mice. TLR13 recognizes Sa19, a specific 23S ribosomal (r) RNA-derived fragment and bacterial modification of Sa19 ablates binding to TLR13, and to antibiotics such as erythromycin. Similarly, RNase A-treated Staphylococcus aureus activate human peripheral blood mononuclear cells (PBMCs) only via TLR2, implying single-stranded (ss) RNA as major stimulant. Here, we identify human TLR8 as functional TLR13 equiva ...[more]