Ontology highlight
ABSTRACT:
SUBMITTER: Ellisdon AM
PROVIDER: S-EPMC4687532 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Ellisdon Andrew M AM Reboul Cyril F CF Panjikar Santosh S Huynh Kitmun K Oellig Christine A CA Winter Kelly L KL Dunstone Michelle A MA Hodgson Wayne C WC Seymour Jamie J Dearden Peter K PK Tweten Rodney K RK Whisstock James C JC McGowan Sheena S
Proceedings of the National Academy of Sciences of the United States of America 20151201 50
The lethal factor in stonefish venom is stonustoxin (SNTX), a heterodimeric cytolytic protein that induces cardiovascular collapse in humans and native predators. Here, using X-ray crystallography, we make the unexpected finding that SNTX is a pore-forming member of an ancient branch of the Membrane Attack Complex-Perforin/Cholesterol-Dependent Cytolysin (MACPF/CDC) superfamily. SNTX comprises two homologous subunits (α and β), each of which comprises an N-terminal pore-forming MACPF/CDC domain, ...[more]